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Anthony Martial, Chris Smalling and Phil Jones are among the players that could be absent for Manchester United against Fulham.
The trio will be assessed on Friday, as will centre-back Eric Bailly after Wednesday's 2-2 draw against Arsenal.
"(We are) still waiting for conclusions, still waiting for people like Martial, Smalling, Jones - people with these kind of doubts," Jose Mourinho said.
Meanwhile, Mourinho does not feel he can trust big-money signing Fred until Manchester United finally find a way to defend.
The Brazil international was not even included in Mourinho's injury-hit squad for Wednesday's 2-2 draw with Arsenal and has only made eight starts for a United side who have already conceded 25 goals.
Mourinho said Fred was adapting "step by step" to life in the Premier League and added: "You have other players in other clubs that needed time (to adjust) and you have some of them that play even less than Fred is playing.
Paul Pogba and Romelu Lukaku will be hoping to return to the starting line-up after being dropped to the bench against the Gunners, but Victor Lindelof (groin) and Alexis Sanchez (hamstring) are out.
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